Author, Reference Year, Location	Health Care Facility (n=), Study Population	Study Objective to Describe	Study Type	Oxygen Therapy Clinical Information Given	Incidence within the entire population screened	Relationship to Oxygen Therapy
Retinopathy of Prematurity:
Southern Asia
Adhikari, 2008, Nepal	Tertiary Care Center (1). Neonates: GA ≤ 34 weeks and/or BW ≤ 1700 gm and who attended the follow up visits	Incidence, risk factors for ROP	Prospective Cohort Study	None	14/55 (25.45%)	Oxygen administration was significantly associated with incidence of ROP (P<.01).
Chaudhari, 2008, India	Tertiary Care Center - NICU (1). Neonates: GA ≤ 32 weeks and BW < 1500g OR GA > 32 weeks and BW ≥ 1500g with additional risk factors for ROP	Risk Factors of ROP	Prospective Cohort Study	None	123/552 (22.3%)	Oxygen therapy a risk factor for ROP development, Univariate odds ratio = 2.75 (1.81-4.19), Multivariate analysis OR=1.89 (1.06-3.39), P=.031
Gayathri, 2015, India	Tertiary Care Hospital (1). Neonates: GA ≤ 34 weeks and birth weight ≤ 1750 g OR GA = 34-36 weeks and BW = 1750-2000g with additional risk factors for ROP	Incidence and Risk Factors for ROP	Prospective Cohort Study	None	21/100 (21%)	Oxygen therapy a significant risk factor for ROP (P=0.013)
Jamil, 2015, Pakistan	Referral Hospital (1). Neonates: GA < 37 weeks and BW < 2000g OR those who were considered high risk for ROP	Demographic and Clinical Features of ROP	Prospective Cohort Study	None	70/285 (24.6%)	The study identified supplemental oxygen therapy as a risk factor for ROP.
Rohit, 2014, India	University Hospital (1). Neonates: BW < 1800 g	Incidence and Risk Factors	Prospective Cohort Study	None	38/278 (13.67%)	Association found between prolonged oxygen exposure (>7 days) and ROP on univariate analysis.
Kumar, 2011, India	Tertiary Care Hospital (1). Neonates: GA ≤ 32 weeks or BW ≤ 1500 g OR GA = 33-34 weeks and BW = 1501-1800 g with risk factors g with risk factors	Risk Factors of ROP needing laser therapy	Retrospective Cohort Study	None	84/704 (11.9%)	Use of oxygen therapy was associated with the development of ROP. OR=2.4 (1.1-5.4), P=.03
Pal, 2015, India	University Hospital NICU (1). Neonates: GA ≤ 35 wks	Incidence and Risk Factors of ROP	Prospective Cohort Study	None	12/50 (24%)	Oxygen therapy determined to be a significant risk factor (P<.001) for development of ROP
Sathar, 2017, India	Referral Hospital (1). Neonates: GA ≤ 32 weeks or BW ≤ 1500g	Describe the Risk Factors of ROP	Prospective Cohort Study	SpO2 was monitored and kept between 93-95%	203/812 (25%)	Oxygen therapy a significant risk factor for ROP, P =.007; OR = 2.042 (1.221-3.416)
Shah, 2009, India	Tertiary Care Eye Referral Hospital (1); children came referred from other hospitals; Neonates born between July 2002 and October 2007 who presented to their hospital with severe ROP.	Characteristics of Neonates with Severe ROP	Retrospective Observational Study	“Most babies had received unmonitored oxygen therapy” – Study did not quantify the amount of children receiving unmonitored oxygen therapy	All	Oxygen therapy a significant risk factor for increased severity of disease. P=.0001.
Ahmed, 2008, Bangladesh	Tertiary Care Hospital with Special Care Nursery. Preterm infants GA< 33 weeks who were admitted for a trial of topical emollient therapy	Description of Children who developed ROP	Case Report	All babies (5) who were found to have ROP received poorly monitored O2 therapy	All	All cases found had been treated with oxygen therapy
Sanghi, 2014, India	Children with Aggressive Posterior ROP who were referred from Level I and II nurseries	Report on the Spectrum and Outcomes of Aggressive Posterior Retinopathy of Prematurity	Retrospective Case Series	All babies (15) received supplemental unmonitored O2	All	All cases found had been treated with oxygen therapy
Sub-Saharan Africa:
Adio, 2014, Nigeria	Tertiary Care Hospital (1). Neonates: GA < 32 completed weeks and BW < 1500g	Incidence and Risk Factors for ROP	Prospective Cohort Study	Oxygen therapy monitored on pulse oximetry, kept between 90-95%	25/53 (47.2%)	Oxygen therapy is found to be a significant risk factor for the development of ROP P=.01.
Fajolu, 2015, Nigeria	University Teaching Hospital (1). Neonates: GA < 32 weeks and BW ≤ 1500g	Incidence and Risk Factors Of ROP	Prospective Cohort Study	None	12/80 (15%)	Oxygen therapy was not significantly associated with ROP P=.11.
Northern Africa:
Hakeem, 2012, Egypt	University Hospital (1). Neonates: GA < 32 weeks and BW ≤ 1500g OR GA > 32 weeks or BW > 1500g and exposed to oxygen therapy for more than 7 days	Risk Factors of ROP	Prospective Cohort Study	None	33/172 (19.2%)	A significant relationship was found between the occurrence of ROP and oxygen therapy (P=0.018).