Hypertension is a major risk factor for several diseases and the leading preventable cause of death worldwide. 1, 2 Recent studies have shown nearly three times as many individuals with hypertension live in low- and middle-income countries (LMICs) as in high-income countries, and that the prevalence of hypertension is increasing in LMICs while declining in high-income countries. 2-3 Additionally, individual patient awareness of personal hypertension in LMICs is approximately half that of high-income populations. 2

Peripheral artery disease (PAD) and other atherosclerotic endpoints are complications of long-standing hypertension. 4 Unlike hypertension, however, the burden of PAD has been less well-characterized in LMICs, though increasing incidence is expected. 5-6 In Haiti, where published rates of hypertension in the adult population vary from 29.5% to 47.1%, there are no reports of PAD prevalence. 7-8 As determining PAD prevalence in addition to hypertension prevalence may identify additional cardiovascular risk-lowering pharmacotherapeutic options, we sought to characterize both hypertension and PAD prevalence in a convenience sample of Haitian adults.



Adults ages 18 years and older in Léogâne, Haiti, were sampled to determine the prevalence of hypertension in this community in summer 2014 and summer 2015. Léogâne is a city of 90,000 residents historically associated with sugarcane production located approximately 18 miles southwest of Port-au-Prince, the capital, and was the epicenter of the 2010 earthquake. The Haitian population is predominantly of West African descent and the Haitian diet has been estimated to include very high levels of sodium intake (up to 30-35 grams daily). 9


During the summer of 2014 and 2015, potential study participants were approached for participation at various geographic locations across the community. These sites were chosen in partnership with health workers who lived within the community to ensure a broad geographic sample. Potential respondents were identified from the houses nearest each chosen location. After providing consent, participants answered a survey in Haitian Kreyol administered by local translators focusing on general health status and risk factors, including knowledge as well as a previous diagnosis of hypertension (English version, Appendix). Following the survey, researchers measured blood pressure readings using an automated cuff (OMRON Model HEM 907XL, Bannockburn, IL) with the patient seated after a minimum of five minutes, as well as height and weight. In summer 2014, participants also had ankle-brachial indices (ABIs) checked while supine after a minimum of five minutes using a Doppler ultrasound kit (Hokanson Model MD6VR Chart Recorder, Bellevue, WA) to assess for evidence of PAD. An exclusion criterion for study participation for 2015 was prior participation in 2014.


Body mass index (BMI) was calculated using weight in kilograms and height in meters, with overweight defined as BMI 25.0-29.9 and obese as BMI ≥30.0. 10, 11 Hypertension was defined according to the Seventh Joint National Committee (JNC 7) guidelines as systolic blood pressure (BP) ≥140 mmHg or diastolic BP ≥90 mmHg. 12 As the Eighth JNC (JNC 8) guidelines were published in the run-up to this study and the 2017 guidelines from multiple societies were released during drafting of this manuscript, sensitivity analyses were also performed per these guidelines. Based on JNC 8 parameters, patients >60 years of age considered to be hypertensive with systolic blood pressure ≥150 mmHg, rather than 140 mmHg. 13 2017 guideline prevalence of hypertension grade was estimated as patients with systolic blood pressure 130-139 mmHg and/or diastolic blood pressure 80-89 mmHg considered stage I hypertensive, with those with either a higher systolic or diastolic pressure considered stage II hypertensive. 13, 14 Reduced ABIs were defined as secondary to mild arterial disease if 0.8-0.9, secondary to moderate arterial disease if 0.5-0.8, and secondary to severe arterial disease if <0.5. 15

Data analysis

Descriptive statistics were performed on survey and measurement data as noted above. All data were analyzed using Stata v. 9.2 (College Station, TX, USA).

Ethical approval

The study was approved by the Institutional Review Board (IRB) at Duke University (Protocol # B0671) as well as the Misyon Sante Fanmi Ayisyen IRB in Haiti (Protocol # 016_5_2013) to ensure cross-cultural ethical standards were met.


Demographic results are presented in Table 1. Overall, 1039 adults were sampled during the study period, 65% of whom were female. Of these, 83.1% (858/1033) had previously had his or her blood pressure checked during his or her lifetime, and 28.8% of the total population (295/1025, or 34.4% of those having previous blood pressure recordings) reported having at least one prior elevated blood pressure. Only 5.5% (57/1034) of subjects currently smoked tobacco at any frequency. Of the 958 participants with both a height and weight recorded, 218 (22.7%) were overweight and 190 (19.8%) were obese, respectively.

Table 1. Population characteristics
Age (years): Number, % (N=1039)
Mean age (SD) 41.3 (17.7)
Median age (IQR) 37 (27-52)
<30 343 (33.0)
30-39 222 (21.4)
40-49 163 (15.7)
50-59 127 (12.2)
60-69 101 (9.7)
70-79 43 (4.1)
≥80 40 (3.9)
Female (%) 672 (64.7)
Median Body Mass Index (IQR)* 22.8 (20.0-26.7)
-Overweight (%)* 218 (22.7)
-Obese (%)* 190 (19.8)
Used any tobacco (%) 57 (5.5)
Previous blood pressure check at any time (%) 858 (82.6)
Previous blood pressure check in previous year (%) 706 (67.9)
Reported comorbidities (%):
Told had hypertension in past 295 (28.4)
Told had diabetes in past 21 (2.0)
Told had ‘heart problems’ in past 18 (1.7)

SD – standard deviation, IQR – interquartile range

*****Body mass index, overweight %, and obese % are calculated from the 958 participants for whom both height and weight were available.

On a single reading, 43.5% (452/1039) participants had an elevated blood pressure of >139 systolic and/or >89 diastolic per JNC 7 guidelines or were taking an antihypertensive medication as verified by the name of the medication. Of these 452 participants, 58.2% (269) were female and 9 were subjects who had a blood pressure of <139/89 reporting current antihypertensive use. One further patient with diabetes had a diastolic blood pressure >80 mmHg, which met treatment thresholds under JNC 7. Hypertension positively correlated with age, ranging from 22.4% between ages 18-29 to 83.1% at >79 years (Table 2). Overall, prevalence of elevated blood pressure surpassed 50% in the 6th decade of life. Under JNC 8 parameters, thirteen fewer participants would be considered hypertensive, for a total prevalence of 42.3% (440/1039). Defining stage I hypertension under the 2017 guidelines would lead to an additional 231 participants (22.2% of the study population) meeting criteria for hypertension, for a population prevalence of 66.3% (702/1059).

Table 2. Participants meeting hypertension criteria, by age group and guideline (N=1039)
2017 Guidelines
Age (years) JNC 7 JNC 8 Stage 1 Stage 2
Overall population (%) 453 (43.6) 440 (42.3) 231 (22.2) 452 (43.5)
<30 77 (22.4) 77 (22.4) 81 (23.6) 77 (22.4)
30-39 77 (34.7) 77 (34.5) 61 (27.4) 77 (34.5)
40-49 76 (46.6)* 75 (46.0) 48 (29.4)* 75 (46.0)
50-59 84 (66.1) 84 (66.1) 20 (15.7) 84 (66.1)
60-69 74 (73.3) 67 (66.3) 16 (15.8) 74 (73.3)
70-79 35 (81.4) 32 (74.4) 1 (2.3) 35 (81.4)
≥80 30 (75.0) 28 (70.0) 4 (10.0) 30 (75.0)

JNC – Joint National Committee

*Includes one patient age 45 years with diabetes and diastolic blood pressure meeting threshold for treatment for patients with diabetes under JNC 7 and 2017 guidelines.

ABIs were measured on 409 participants in order to assess arterial disease (Table 3). Overall, 31 of these 409 participants (7.6%) had an ABI ≤0.9, while 11 (2.7%) had an ABI <0.8, and none had an ABI <0.5. Of participants with a reduced ABI, 9 were ≥65 years. Of the 31 with any reduction in ABI, only 14 (45.1%) were hypertensive on the single blood pressure measurement. Of those with an ABI <0.8, 8 of 11 (72.7%) were hypertensive. An additional three patients (0.7%) had ABI >1.4.

Table 3. Prevalence of peripheral arterial disease, by age group and severity
Ankle-brachial indices (N=409)
Age (years) Severe (<0.5) Moderate (0.5-0.79) Mild (0.8-0.9)
Overall population (%) 0 (0.0) 11 (2.7) 20 (4.9)
<30 0 (0.0) 3 (0.7) 10 (2.4)
30-39 0 (0.0) 1 (0.2) 1 (0.2)
40-49 0 (0.0) 1 (0.2) 2 (0.5)
50-59 0 (0.0) 1 (0.2) 1 (0.2)
60-69 0 (0.0) 1 (0.2) 1 (0.2)
70-79 0 (0.0) 0 (0.0) 1 (0.2)
≥80 0 (0.0) 4 (1.0) 4 (1.0)

Overall, 98.9% of participants (1,024/1,035) endorsed some awareness of hypertension, and a similar high frequency (99.6%, or 1,026/1,030) stated they would be willing to take a medication for hypertension. A high frequency of participants also endorsed awareness that hypertension generally led to health problems (84.7%, or 856/1,027) and specific outcomes such as heart attacks (71.5%, or 449/628) and strokes (96.0%, or 603/628). Alternatively, few participants were aware hypertension could be asymptomatic (8.0%, or 82/1,028).


Our results demonstrate that hypertension is highly prevalent in a young Haitian population with significant rates of being overweight or obese. The prevalence of hypertension increased across the lifespan in this population, affecting more than half of participants >50 years of age. However, relatively few hypertensive patients had evidence of concurrent PAD, as determined by ABI measurement.

Similar to previous individual studies in Haiti, our estimates of hypertension showed a substantial proportion of patients with hypertension across all ages. Dickstein et al., whose study was based on patients presenting to clinics in and around Léogâne, found 41.9% of the rural population and 29.5% of the urban population >40 years old had hypertension. 7 Our study, in which patients were sampled within the community at large, showed a prevalence of 62.8% for elevated blood pressures in persons >40 years and 43.5% for the overall sample. These findings correspond closely to a study performed by Jean-Baptiste et al. in Port-au-Prince, where hypertension was noted in 69.1% of males and 67.2% of females ≥40 years. 16 This is compared to the population-wide estimated rates of 25.5% for men and 26.7% for women ≥20 years based on imputed values from the Jean-Baptiste study and results from Mexico, Jamaica, and Grenada. 2, 16

Using the latest guideline definition for hypertension in this population would increase the prevalence of disease across all age groups and by 55% overall. This is similar to recent work from a global sample of adults from 80 countries (including 127 adults in Haiti), wherein adoption of the newest hypertension definition would relatively increase the imputed hypertensive population globally by 64%. 17 Unfortunately, this study did not publish country-level rates of hypertension under any definition. 17 In our population, the increase in hypertension with a definition change would be most pronounced in the younger age groups, with the hypertensive population <40 years almost doubling. A much smaller population increase would require pharmacotherapy, however, as only an additional 10 patients (0.9% of the population) would be recommended for treatment based on stage I hypertension and age ≥65 years. For context, a recent US analysis noted a recommended increase in medication use of 1.9% under 2017 guidelines based on the nationally-representative National Health and Nutrition Examination Survey. 18

Our findings regarding PAD are consistent with Global Burden of Disease project results. That project estimated PAD in LMICs to increase from 1.2% in aged 25-29 year-old males and 4.0% in similarly aged females to 21.5% and 18.7%, respectively, in those >95 years old. 19 These estimates were taken from only 12 studies in LMICs, however, and only one of the studies included another nation, such as Haiti, meeting the World Bank’s criteria for a low-income country. 20, 21 This single study, performed partially in the Central African Republic, found 15.0% overall prevalence of PAD in persons ≥65 years of age, with higher rates (17.2%) in women than men (11.9%). 21 The existence of only one study emphasizes the need to further investigate PAD in low-income countries. In our population, only 9 of 31 participants with PAD were ≥65 years, implying many possible patients may be missed by studying PAD in only elder populations in LMICs. Additionally, identifying younger patients with evidence of PAD may improve opportunities for risk factor modification.

It is encouraging that high rates of participants endorsed knowledge of hypertension as a health condition and downstream health effects. While some of this reported awareness may be due to social desirability bias, rates in this community are likely higher than the aggregated LMIC rate of 37.9% awareness from a systematic review. 2 One possible reason for increased hypertension awareness in this community may be an influx of healthcare resources in the aftermath of the 2010 earthquake, which increased the number and reach of health care personnel over a several-year period. In spite of these resources, however, only nine patients were currently taking an antihypertensive medication they could name.

One limitation of this study is the use of a convenience sample. While different geographic areas in the community were targeted, random sites chosen by geographic identifiers were not used for sampling. However, the density of development in the community allowed for extensive sampling over the course of the study period that likely limited variation based on geography alone. This sample was not able to be further adjusted based on national population data, as no formal census has been undertaken within Haiti since 2003. An additional limitation was use of a single cross-sectional blood pressure measurement for determination of blood pressure values; however, this methodology allowed us to sample patients not presenting to a clinic setting. Additionally, we followed standardized measurement protocols with rest periods before measurement to minimize the influence of immediate work or activity on blood pressure. Moreover, recent work indicates that repeated measurements during a single period only reduces the population estimated to have hypertension by 3.9%. 17 Furthermore, given so few participants were taking blood pressure medications, we do not anticipate additional significant differences to have been present if measured repeatedly in a clinic setting.

Programmatic implications of this work include the need to target a wide age range for efforts related to hypertension measurement and treatment. To that end, we plan to use clinical partners in the area to screen and treat hypertensive patients chronically. Fortunately, few persons in the community routinely use tobacco and relatively few have PAD, which signals an opportunity to focus on treating patients for hypertension to reduce incidence of comorbid vascular events. In patients in whom symptomatic PAD is identified, low-risk pharmacotherapy could be initiated with aspirin consistent with known beneficial evidence without substantially adding to health resource limitations surrounding cost. 22-23


In conclusion, we found a community sample of Haitians had rates of hypertension similar to previous populations studied within the country when using older guidelines. Adopting a hypertension definition consistent with the 2017 guidelines would lead to 55% higher prevalence of hypertension in this population although the number recommended for pharmacotherapy would only increase by 0.9%. Additionally, we found lower rates of peripheral artery disease than noted in the only other study measuring ABIs in a LMIC. These findings identify opportunities for chronic risk-factor modification and management to limit incident cardiovascular disease in a low-income setting.


The authors wish to thank the following personnel for assisting with survey administration: Garland Austin, Lydia Bradford, Elle Gault, Zachary Morrow, Tanya Thomas, Lillian Zerihun, and June Zhang.

Funding: This work was supported through the Duke Student Research Training Program through Duke University.

Competing interests: The authors completed the Unified Competing Interest form at ww.icmje.org/coi_disclosure.pdf (available upon request from the corresponding author), and declare no conflicts of interest.

Correspondence to:
Joel C. Boggan, M.D., M.P.H.
Hospital Medicine Team (111M)
Durham VA Medical Center
508 Fulton St.
Durham, NC 27705 USA
[email protected]